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  • The scene where 乔治 is speaking about health care while John and Denise are watching television, was also shot with footage of 阿尔·戈尔, because the election winner had not yet been declared at the time of shooting.
  • The movie was shot in a group of provincial government buildings in Toronto, Ontario. Adjacent to filming, is a hospital. On at least one occasion, filming blocked off access to the emergency room of the real hospital.
  • The scene where Denise (Kimberly Elise) calls John (Denzel Washington) from the hospital had to be re-shot because she was wearing the wrong dress.
  • John Q and his son Mikey's blood type is B Positive. This is the third most common blood type in the world, with around 8.5% of people having it.
  • Denzel Washington and Kevin Connolly appeared in Antwone Fisher (2002), which Washington directed.
  • Denzel Washington and Ethan Suplee appeared in Unstoppable (2010)
  • Kimberly Elise and Denzel Washington were also in The Great Debaters, (2007).
  • One of the recurring themes in this movie is having faith and hope. Gus tells John Q to have faith. His wife Denise attends church and reminds John to pray. Lester tells John that he has to accept the situation and put it in God's hands. The irony in this is that John Q and Mikey's blood type is B Positive. Or, Be positive, have hope.
  • Denzel Washington and Kimberly Elise also appear together in The Manchurian Candidate which was directed by Jonathan Demme uncle of Ted Demme.
  • Despite its thrilling progression, the cast actually did laugh when the eccentric couple broke up in the hospital.
  • During the first scene, the make of the truck that hit the woman's car, and killed her afterwards, is "Mack". This can be seen on the front of the truck, and after that throughout the whole movie, Denzel wears a "Mack" cap on many occasions.
  • The handgun that John uses is a Beretta 92FS.
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