Filmed in 2000, Miramax films planned on releasing the film in late 2001, but shelved it indefinitely in the US. A number of reasons were given for the delay, from the unlikeable nature of the central heroine to writer Elizabeth Wurtzel's offensive comments about 9/11, to the fact that Wurtzel noted that the movie was "horrible." The movie finally debuted on the Starz! network in 2005 when, following the exit of 哈维·韦恩斯坦 and 鲍伯·韦恩斯坦 from Miramax, all pending films were released, in one form or another.
When Elizabeth Wurtzel is writing the piece on Bruce Springsteen, a pack of Morleys, the fictional cigarette brand from the The X Files (1993) and many other movies and TV shows can be seen on her desk.
In an interview just before the film was finally released, Christina Ricci, who was 20 at the time, admitted that doing her first nude scene ever in Prozac Nation was frightening. She said during production that director Erik Skjoldbjaerg decided that a nude scene would show the character's complete emotional "nakedness," even though nudity wasn't in the script or even discussed before production began. Ricci agreed but requested a closed set and then she called her co-star Michelle Williams to come watch the monitor and let her know that everything looked okay. Ricci went on to perform nude scenes in several of her later films.